Evaluation of Neuroprotective Activity of Chrysin Nanoparticles Using Scopalamine Induced Neuroinflammation in the Rat Model of Alzheimer’s Disease
نویسندگان
چکیده
Background: scopolamine induced neuroinflammation limits its long-term clinical use. Several agents/strategies were attempted to prevent neuroinflammatory but not found suitable for use.
 Objective: To investigate the neuroprotective activity of chrysin nanoparticle on neuroinflammation.
 Material and Method: Male Albino wistarrats (180- 230 grms) evenly divided into 5 groups. Group I&II served as control (distilled water 10ml/kg) diseases (scopolamine) 100mg/kg per os treated 4 weeks, group III standard which received Donepezil (1.5mg/kg) ,while IV V are simultaneously with (50mg/kg 100 mg/kg) orally up weeks. On 29 30 day behavioral parameters brain isolated biochemical at same time rat brains used histological studies.
 Results: Treatment caused evidence by marked elevation in AchE, GSH, catalase, super oxide Dismutase, Elevated plus maze,Y-maze Open field test. SLN decrease dismutase, GSH respectively. increase activities SOD, crossing, Rearing, Grooming. Histopathological changes also showed protective nature
منابع مشابه
the use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach
abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
15 صفحه اولthe effect of using model essays on the develpment of writing proficiency of iranina pre-intermediate efl learners
abstract the present study was conducted to investigate the effect of using model essays on the development of writing proficiency of iranian pre-intermediate efl learners. to fulfill the purpose of the study, 55 pre- intermediate learners of parsa language institute were chosen by means of administering proficiency test. based on the results of the pretest, two matched groups, one as the expe...
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولcontrol of the optical properties of nanoparticles by laser fields
در این پایان نامه، درهمتنیدگی بین یک سیستم نقطه کوانتومی دوگانه(مولکول نقطه کوانتومی) و میدان مورد مطالعه قرار گرفته است. از آنتروپی ون نیومن به عنوان ابزاری برای بررسی درهمتنیدگی بین اتم و میدان استفاده شده و تاثیر پارامترهای مختلف، نظیر تونل زنی(که توسط تغییر ولتاژ ایجاد می شود)، شدت میدان و نسبت دو گسیل خودبخودی بر رفتار درجه درهمتنیدگی سیستم بررسی شده اشت.با تغییر هر یک از این پارامترها، در...
15 صفحه اولthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of innovations in applied pharmaceutical sciences
سال: 2023
ISSN: ['2455-5177']
DOI: https://doi.org/10.37022/jiaps.v8i2.452